Development of a New Risk Scoring System Based on Spleen Involvement and the Lymphocyte/Monocyte Ratio for Follicular Lymphoma Patients

Background: This study aimed to retrospectively evaluate a large Chinses cohort's baseline characters and develop a new predictive scoring system.

Methods: A total of 530 FL patients were reviewed, and 376 newly diagnosed 1-3a FL patients from January 2000 to October 2020 were enrolled in our retrospective cohort.

Results: Progression-free survival (PFS) was assessed as the first endpoint; the 2-year and 5-year PFS were 79.6% and 66.8%, respectively. A new risk scoring system (SLMR) was established after the univariable and multivariable analyses, and four independent factors such as β2-MG, LDH, LMR, and spleen involvement were detected by FDG-PET imaging were included. The SLMR was compared with the existing models using discrimination and calibration, and k-fold cross-validation was performed for internal validation. Our cohort classified patients into three groups (low-, intermediate- and high) according to the SLMR and showed the best model performance.

No relevant conflicts of interest to declare.